Abstract Objective: To establish the diagnostic concentration range of urine cystatin C and the control level of urine cystatin C for patients with renal injury, and to help promote the establishment of standardization of urine cystatin C detection. Methods: 150 urine specimens and blood specimens from kidney injury patients and healthy people were collected, and stored in the refrigerator at −80˚C for later use. After the specimens were collected, they were uniformly tested. Comparing the difference of blood and urine cystatin C between the kidney injury group and the healthy control group, the application value of urine cystatin C in the diagnosis and treatment of kidney injury was put forward. Results: The concentrations of cystatin C in urine and blood of renal injury group were 1.04 ± 2.14 mg/L and 1.94 ± 2.36 mg/L respectively; the concentrations of cystatin C in urine and blood of healthy control group were 0.11 ± 0.05 mg/L and 0.83 ± 0.20 mg/L respectively. The urine and blood cystatin C of the kidney injury group were significantly higher than those of the healthy control group. Compared the results of the two groups, the t values were 5.3210 and 5.7399, respectively. The P value is 0.0000; the difference is statistically significant; in comparison of urine and blood cystatin C in the kidney injury group, the value is that t = 3.4600, P = 0.0003; in comparison of urine and blood cystatin C in the healthy control group, the value is that t = 42.7744, P = 0.0000. By investigating the urine cystatin C concentration of patients with kidney injury, whether it is kidney injury or healthy controls, urine cystatin C is significantly lower than blood cystatin C. Conclusion: According to the results of this study, the concentration of urinary cystatin C in the healthy control group is 0.11 ± 0.05 mg/L. The reference interval of urinary cystatin C proposed in this study is 0.06 - 0.16 mg/L, which can be established by comprehensive multi center research. Through a multi-center study of the baseline level of urinary cystatin C in patients with renal injury, the diagnostic concentration interval of urinary cystatin C and the control level of urine cystatin C for renal injury patients were established.

Abstract Four ULF (0.01 Hz - 20 Hz) electromagnetic stations had been gradually established and put into service from 2010 to 2011 in Zhaotong area, Yunnan province. Two stations of Qiaojia and Yongshan have been running with continuous and high quality recordings and free of influence of solar activities, like magnetic storms. In this investigation, daily recordings from 1 January 2020 to 22 May 2021 have been examined of these both stations. The results show that weak anomalous signals appeared at the beginning of March 2021 with relative low magnitudes of 0.6 nT at Qiaojia station and 0.3 nT at Yongshan station. At the end of this month, the emissions gained an abrupt increase and the amplitudes reached up to 3.8 nT at Qiaojia station and 1.2 nT at Yongsha station. Then, the amplitude decreased to be 0.5 - 1.5 nT and 0.6 - 1.3 nT respectively at both stations but with a high variation frequency in all components. This situation lasted till the Yangbi MS 6.4 earthquake happened on May 21, 2021, more than 300 km away from these two ULF observing stations. Totally, the ULF magnetic emissions had been characterized by a synchronous variation in all components at two observing stations.

Abstract This paper is a study to understand how climate changed last fifty years. There are two theories: the first one considers the solar variability and the influence of those alterations on climate; the second one blames human activity and the consequences on temperatures and disruption on the environment created by humans. Our conclusions pointed out that dimensions involved between Earth and Sun, and Earth/Atmosphere, the second one can disturb the temperature on Earth’s surface and make seasonality variations impossible to be explained only by Sun/Earth connections.

Abstract Objective: To understand the effects of several commonly used antipsychotics on the renal function of patients with mental illness. Method: Collected patients with mental illness who were hospitalized in our hospital from January 2020 to June 2021, and selected as the re search subjects patients with psychiatric disorders who were treated with 2 kinds of commonly used antipsychotic drugs; and collected 3 ml of venous blood before treatment and one month after treatment for renal function tests; observed the changes of renal function indexes before and after treatment. Results: In the collected 694 patients with mental illness, before using antipsychotic drugs, the renal function indexes were BUN: 4.42 ± 1.92 mmol/l; Cr: 70.97 ± 16.92 μmol/l; CCr: 88.37 ± 21.07 ml/min; β2-MG: 1.67 ± 0.61 mg/L; UA: 359.90 ± 112.82 μmol/l; CYS-C: 0.92 ± 0.24 mg/L. One month after using antipsychotics, BUN: 3.77 ± 1.37 mmol/l; Cr: 70.46 ± 16.71 μmol/l; CCr: 87.78 ± 20.63 ml/min; β2-MG: 1.75 ± 0.64 mg/L; UA: 332.53 ± 91.48 umol/l; CYS-C: 0.92 ± 0.24 mg/L; the renal function indexes of urea nitrogen, β2 microglobulin, uric acid and other items all changed significantly. The differences before and after treatment were statistically significant, P < 0.01. Conclusion: Several commonly used antipsychotic drugs have a greater impact on the renal function of patients with mental illness. During the treatment, the changes in renal function should be monitored regularly, if severe renal damage is found, the treatment plan or dosage should be adjusted in time to avoid endangering life.